Program

Wednesday, August 7

18:00 – 19:00                          Registration / Light refreshments

19:00 – 20:15                          Session I

TRANSCRIPTION and RNA

Chairs:                                   John Coffin and Karen Beemon

19:00 – 19:25 Venkat SRK Yedavalli, National Institute of Allergy and Infectious Diseases; Role of PTBP-1 in post-transcriptional processing of HIV-1 transcripts
19:25 – 19:50 Leslie J. Parent, Penn State College of Medicine; Molecular Mechanisms of Retroviral Genomic RNA Recognition and Packaging
19:50 – 20:15 Bryan R. Cullen, Duke University;  In depth analysis of the interaction of HIV‑1 with cellular microRNA biogenesis and effector mechanisms

Thursday, August 8

9:00 – 11:50                            Session II

ONCOGENESIS, LATENCY and PATHOGENESIS

Chairs:                                   Sandra Ruscetti and Naomi Rosenberg

9:00 – 9:25 David J. Griffiths, Moredun Research Institute; Precision-cut lung slices: an in vitro model system for ovine pulmonary adenocarcinoma
9:25 – 9:50 James Justice IV, Johns Hopkins University; High throughput sequencing of integration sites to identify genes involved in ALV-induced lymphomas
9:50 – 10:15 James C Neil, University of Glasgow; Moloney murine leukaemia virus bypass of tumour suppressor pathways in lymphomagenesis : new insights
10:15 – 10:35 Coffee Break
10:35 – 11:00 Patrick L. Green, The Ohio State University; Role of PRMT5 over-expression in HTLV-1-driven cellular transformation and leukemia
11:00 – 11:25 Caroline Leroux, INRA, Université Lyon; Interstitial lung disease in horses infected by EIAV (Equine Infectious Anemia Virus)
11:25 – 11:50 Marcelo De las Heras, Universidad de Zaragoza;  Natural solitary tumors associated with Jaagsiekte retrovirus in sheep are heterogeneous and contain cells positive to markers identifying progenitor cells in lung repair.
11:50 – 13:00 Lunch – Decode Genetics

13:05 – 16:00                          Session III

ENTRY and VIRAL TRAFFICKING

Chairs:                                   Monica Roth and Stephen Goff

13:05 – 13:30 Stephen Goff, Columbia University; Stable microtubules and HIV-1 trafficking
13:30 – 13:55 Lorraine M. Albritton, University of Tennessee; The intracellular destination to which a receptor trafficks virus limits infection levels
13:55 – 14:20 Jiri Hejnar, Institute of Molecular Genetics, Prague; The avian Tvj receptor is disabled by multiple parallel amino acid deletions/substitutions in ALV-J-resistant species
14:20 – 14:45 Kathryn S. Jones, Frederick National Laboratory for Cancer Research; Evidence that productive infection of primary dendritic cells by cell-free HTLV-1 occurs following entry via macropinocytosis-like pathway
14:45 – 15:10 Thomas J Hope, Northwestern University, Feinberg School of Medicine; First Cell(s) infected by vaginal transmission of Immunodeficiency Virus in Rhesus Macaques
15:10 – 15:35 Ronald Swanstrom, University of North Carolina at Chapel Hill; The limited nature of macrophage tropism for the primate lentivirus HIV-1
15:35 – 15:55 Coffee Break
16:00 – 16:45 Ashley T. Haase, University of Minnesota, Bjorn Sigurdsson Memorial lecture
16:45 – 17:30 Reception
17:30 – 19:00 Poster session
19:15 Dinner – Nordic House

Friday, August 9

8:30 – 12:30                            Session IV

EARLY EVENTS and RESTRICTION FACTORS

Chairs:                                    Lorraine Albritton and Christine Kozak

8:30 – 8:55 Mamuka Kvaratskhelia, The Ohio State University; BET proteins promote efficient murine leukemia virus integration at transcription start sites
8:55 – 9:20 Monica J. Roth, Rutgers – RWJMS; MLV p12 and IN proteins in tethering and integration
9:20 – 9:45 Hung Fan, University of California, Irvine; Murine leukemia virus glycosylated Gag: effects on virus structure and composition, and resistance to host restriction factors
9:45 – 10:10 Susan R. Ross, University of Pennsylvania; Human APOBEC3A and APOBEC3G restrict murine retrovirus infection in vivo
10:10 – 10:30 Coffee Break
10:30 – 10:55 Yoko Aida, RIKEN; Nuclear import process as potential antiviral target for AIDS
10:55 – 11:20 Bjørn A. Nexø, Aarhus University, Restriction genes for retroviruses influence the risk of Multiple Sclerosis
11:20 – 11:45 Moshe Kotler, The Hebrew University of Jerusalem; Novel APOBEC3G properties allow it to be an efficient mutator of newly synthesized HIV-1 DNA
11:45 – 12:10 Reuben S. Harris, University of Minnesota; Primate and nonprimate lentiviral Vif cofactor requirements
12:10 – 12:30 Valgerdur Andrésdóttir, University of Iceland; The Vif protein of maedi-visna virus
12:30 – 13:30 Lunch – Decode Genetics

13:30 – 17:05                          Session V      

ZOONOSIS, NEW VIRUSES and ENDOGENOUS VIRUSES

Chairs:                                   Jaquelin Dudley and Patrick Green

13:30 – 14:15 Keynote lecture
Maribeth Eiden,
National Institutes of Health; A novel exogenous retrovirus isolated from koalas with malignant neoplasias in a U.S. zoo
14:15 – 14:40 Takayuki Miyazawa, Kyoto University; Multiple invasions of KoRV-related gammaretroviruses in the koala genome
14:40 – 15:05 Stanislav Indik, University of Veterinary Medicine, Vienna; Specific adaptation of MMTV that enables efficient replication in human cells
15:05 – 15:30 Christine A. Kozak, National Institute of Allergy and Infectious Diseases; Endogenous gammaretrovirus acquisition in Mus musculus subspecies carrying functional variants of the XPR1 virus receptor
15:30 – 15:50 Coffee Break
15:50 – 16:15 Andrew Mason, University of Alberta; Human Betaretrovirus Integration in Patients with Primary Biliary Cirrhosis
16:15 – 16:40 Robin A Weiss, University College, London; Sheep in wolves’ clothing: Lentiviral pseudotypes for surveillance of emerging and zoonotic virus infections
16:40 – 17:05 Rafael Contreras-Galindo, University of Michigan; HIV Infection Reveals Wide-Spread Expansion of Novel Centromeric Human Endogenous Retroviruses
18:00 Blue Lagoon – Bath and Conference Dinner

Saturday, August 10

9:30 – 10:45                            Session VI

ASSEMBLY and ACCESSORY PROTEINS

Chair:                                     Leslie Parent

9:30 – 9:55 Jaisri Lingappa, University of Washington; The highly conserved retroviral Gag major homology region binds to the highly conserved cellular factor ABCE1, which functions as an adaptor during capsid assembly
9:55 – 10:20 Jaquelin Dudley, The University of Texas at Austin; Function and trafficking of the MMTV Rem C-terminus
10:20 – 10:45 Jacob Hochman, The Hebrew University of Jerusalem; MMTV-p14: A Multi-functional Signal Peptide with Immune Modulating Characteristics
10:45 – 11:00 Coffee Break

11:00 – 13:35                          Session VII

IMMUNE RESPONSES

Chairs:                                   Kathryn Jones and Eric Rassart

11:00 – 11:25 Paul Jolicoeur, University of Montreal; HIV-1 Nef induces accumulation of Treg, but these retain suppressive functions
11:25 – 11:50 Gregg A. Dean, Colorado State University; Novel Mechanism of Microbial Translocation in FIV Infected Cats
11:50 – 12:15 Mary Poss, Penn State University; Viral population dynamics and host transcriptomics in dual and single FIVC infections
12:15 – 12:40 Karin E. Peterson, NIH/Rocky Mountain Laboratories; Neuropeptide Y influences monocyte/macrophage recruitment to the CNS following retrovirus infection
12:40 – 13:05 Kathrin Gibbert, University Hospital, Essen; Distinct roles of NK cells in viral immunity during different phases of an acute retroviral infection and their improved effector function by different Interferon-α subtypes